The aim of the project is to develop a vascular prosthesis with a unique wall design. It is designed to tolerate low flow rates. It is a sandwich composite combining extruded collagen with a polyester knitted scaffold that respects the structure of the native blood vessel. Integration of the scaffold between inner and outer collagen layers will improve the biomechanical response of the prosthesis, which will approach the mechanics of native vascular wall in the circumferential direction. This modification will allow the transmission of the pulse wave and thus a better function of the prosthesis in vascular system. The technology will allow programming of tension of polyester scaffold in collagen allowing only limiting dilatation. Controlled extrusion will be used in fabrication of the vascular prosthesis. Extrusion allows collagen fibre bundles to be oriented in dominant directions, similar to native vascular wall. This is directly related to biomechanical response of the prosthesis. The utilized technology is able to create a prosthesis with anisotropic mechanical properties corresponding to physiological nature of the vascular wall. The design used allows for an increase in elasticity at anastomosis site, due to the connection of two circumferentially similarly elastic tubes. These properties will positively influence the haemodynamics of pulsatile blood flow. The research team is a multidisciplinary consortium of clinical and academic institutions that have been working intensively together for a long time. The project activities will include detailed characterisation of collagen isolates, mechanical and material testing of components and intermediates, optimised extrusion method and biological testing under in vitro and in vivo conditions. The outcome of the project will be a biomimetic composite low flow vascular prosthesis with described effects of individual manufacturing steps and prosthesis components on its physical properties.