Research into natural polymers and their solutions, such as collagen, often ignores the effects of extreme external influences on their internal structure, physical properties, thermodynamics and mechanics. This experimental project is focused on the research of changes in the structure and composition of collagen mass due to irradiation and the action of very high pressure. The evaluation of these effects will be performed on the basis of chemical and structural analysis aimed at describing the change in secondary structure, stability and degree of collagen degradation.